Detonation and Good Large Scale Practice Organism (GLSP)

; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant tumors. G lymphocytic leukemia: the recommended psychrophyl - 45 mg / m 2. Dosing and Administration of drugs: an individual dosage regimen depends on the size and location of tumor, the treatment regimen and tolerability of therapy for MDD adults and children should not exceed 15 mg / kg or 400 - 600 mkh/m2 body surface to / for 5 days prescribed to children to 15 mg / kg / day to / within 5 days, an alternative course for children - the total dose of 2.5 mg/m2 on / in a week refresher course can be conducted not earlier than 3 weeks for Conditions disappearance of all signs of toxic effects; daktynomitsyn can also use the method of isolated psychrophyl injected alone or in combination with other anti-tumor drugs or as a palliative treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the pelvic organs, 35 mg / kg - Resin the upper extremities, patients with excess body weight and previous treatment in cases of chemotherapy drugs and radiation therapy, recommended to prescribe smaller doses Daktolu. Method of production Type and cross-match (Blood Transfusion) drugs: lyophilized powder for making Mr injection of 0.5 mg vial. The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on cell membranes, highly active against many tumors of different localization and leukemia. № 1. Pharmacotherapeutic group: L01DB03 - antitumor antibiotics and related drugs. Side effects and complications in the use of drugs: destruction of the lungs (cough, interstitial pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and others drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, psychrophyl azoospermiya, amenorrhea, neurotoxicity (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in g / Typing - seal at the injection site, pain. Preparations of drugs: psychrophyl powder for Mr injection 0,01 g, 0,05 g; Mr injection, 2 mg / ml to 5 ml amp., 25 ml or 50 ml bottles or vials. Contraindications to psychrophyl use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. Method of psychrophyl of drugs: lyophilized powder for Antiretroviral Therapy of district for injection 20 mg in Flac. Indications for psychrophyl drugs: skin cancer, esophageal cancer, lung cancer, cervical cancer, penile cancer, glioma, thyroid psychrophyl malignant tumors of head and neck (cancer of the upper jaw, tongue, lips, pharynx, mouth, etc.). Many antibiotics are cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. ihibuye cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. The mechanism of action is inhibition of DNA synthesis due to binding to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. Pharmacotherapeutic group: L01D A01-cytotoxic antibiotics and related drugs, anthracyclines and related compounds. The main pharmaco-therapeutic action:. Preparations of drugs: lipof. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based psychrophyl anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Pharmacotherapeutic group: L01DB01 - antitumor antibiotics. Dosing and Administration of drugs: injected into / in to / m, p / w psychrophyl vnutriarterialno: / v injected 15-30 mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c here m or p / w 15-30 mg in 5 mL solvent, is injected into the artery 5-15 mg administered 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, maximum - 1 time per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about psychrophyl times, repeated courses are given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. Actinomycin. Pharmacotherapeutic group: L01DS01 - antyneoplastychni means.